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Research Article| Volume 27, ISSUE 4, P699-723, July 1997

Osteoarthritis

Joint Anatomy, Physiology, and Pathobiology
  • Spencer A. Johnston
    Correspondence
    Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061–0442.
    Affiliations
    From the Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia
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      Osteoarthritis can be defined as a disorder of movable joints characterized by deterioration of articular cartilage, osteophyte formation and bone remodeling, changes in periarticular tissues, and a low-grade, nonpurulent inflammation of variable degree. This article reviews normal joint anatomy and function, as well as biochemical, biomechanical, and pathologic changes that are characteristic of osteoarthritis.
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