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References
- Cognitive dysfunction syndrome: a disease of canine and feline brain aging.Vet Clin Small Anim. 2012; 42: 749-768
- Aging in the canine and feline brain.Vet Clin Small Anim. 2014; 44: 1113-1129
- Cognitive aging in dogs.Gerontology. 2018; 64: 165-171
- Encephalopathies: disorders of the brain.in: Dewey C.W. da Costa R.C. Practical guide to canine and feline neurology. 3rd edition. Wiley-Blackwell, Ames (IA)2016: 141-236
- Vascular cognitive impairment.Nat Rev Dis Primers. 2018; https://doi.org/10.1038/nrdp2018.3
- Cognitive disturbances in old dogs suffering from the canine counterpart of Alzheimer’s disease.Brain Res. 2006; 1069: 216-226
- A new direction for Alzheimer’s research.Neural Regen Res. 2018; 13: 190-193
- Mitochondrial abnormalities in Parkinson’s disease and Alzheimer’s disease: can mitochondria be targeted therapeutically?.Biochem Soc Trans. 2018; 46: 891-909
- Mitochondria and Alzheimer’s disease: the role of mitochondrial genetic variation.Curr Genet Med Rep. 2018; 6: 1-10
- Magnetic resonance spectroscopy reveals abnormalities of glucose metabolism in the Alzheimer’s brain.Ann Clin Transl Neurol. 2018; 5: 262-272
- Dogs with cognitive dysfunction as a spontaneous model for early Alzheimer’s disease: a translational study of neuropathological and inflammatory markers.J Alzheimers Dis. 2016; 52: 433-449
- Under diagnosis of canine cognitive dysfunction: a cross-sectional survey of older companion dogs.Vet J. 2010; 184: 277-281
- Prevalence of behavioral changes associated with age-related cognitive impairment in dogs.J Am Vet Med Assoc. 2001; 218: 1787-1791
- Prevalence and risk factors of behavioural changes associated with age-related cognitive impairment in geriatric dogs.J Small Anim Pract. 2009; 50: 87-91
- Cognitive dysfunction, progression of age-related behavioral changes, biomarkers, and survival in dogs more than 8 years old.J Vet Intern Med. 2015; 29: 1569-1577
- Amyloid β-peptide and oligomers in the brain and CSF of aged canines.J Alzheimers Dis. 2010; 20: 637-646
- Age-related changes in the brain of the dog.Vet Pathol. 1999; 36: 202-211
- Frontal lobe volume, function, and β-amyloid pathology in a canine model of aging.J Neurosci. 2004; 24: 8205-8213
- A canine model of Alzheimer’s disease generated by overexpressing a mutated human amyloid precursor protein.Int J Mol Med. 2014; 33: 1003-1012
- β-amyloid accumulation correlates with cognitive dysfunction in the aged canine.Neurobiol Learn Mem. 1996; 66: 11-23
- The relation between canine cognitive dysfunction and age-related brain lesions.Pathology. 2016; 78: 997-1006
- Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.Int J Mol Sci. 2018; https://doi.org/10.3390/ijms19041092
- Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.Nature. 2017; 552: 187-193
- Brain glucose metabolism: role of Wnt signaling in the metabolic impairment in Alzheimer’s disease.Neurosci Biobehav Rev. 2017; 80: 316-328
- Young to middle-aged dogs with high amyloid-β levels in cerebrospinal fluid are impaired on learning in standard cognition tests.J Alzheimers Dis. 2017; 56: 763-774
- An observational study with long-term follow-up of canine cognitive dysfunction: clinical characteristics, survival, and risk factors.J Vet Intern Med. 2013; 27: 822-829
- Risk factors for canine cognitive dysfunction syndrome in Slovakia.Acta Vet Scand. 2017; https://doi.org/10.1186/s13028-016-0196-5
- Temporal lobe epilepsy-induced neurodegeneration and cognitive deficits: implications for aging.J Chem Neuroanat. 2018; https://doi.org/10.1016/j.chemneu.2018.02.005
- Cognitive dysfunction in naturally occurring canine epilepsy.PLoS One. 2018; https://doi.org/10.1371/journal.pone.0192182
- Pharmacotherapeutic strategies for treating epilepsy in patients with Alzheimer’s disease.Expert Opin Pharmacother. 2018; 11: 1201-1209
- Vestibular impairment in dementia.Oto Neurotol. 2016; 8: 1137-1142
- Effect of age and severity of cognitive dysfunction on two simple tasks in pet dogs.Vet J. 2013; 198: 176-181
- Leukoaraiosis-new concepts and modern imaging.Pol J Radiol. 2018; 83: e76-e81
- Magnetic resonance imaging features of leukoaraiosis in elderly dogs.Vet Radiol Ultrasound. 2017; 58: 389-398
- Measurement of interthalamic adhesion thickness as a criteria for brain atrophy in dogs with and without cognitive dysfunction (dementia).Vet Radiol Ultrasound. 2005; 46: 452-457
- Evaluation of interthalamic adhesion size as an indicator of brain atrophy in dogs with and without cognitive dysfunction.Vet Radiol Ultrasound. 2017; 58: 581-587
- Emerging concepts in sporadic cerebral amyloid angiopathy.Brain. 2017; 140: 1829-1840
- Neurovascular dysfunction in dementia-human cellular models and molecular mechanisms.Clin Sci. 2018; 132: 399-418
- Brain hemorrhages in cerebral amyloid angiopathy.Semin Thromb Hemost. 2013; 39: 955-962
- Cerebral microhemorrhages: mechanisms, consequences, and prevention.Am J Physiol Heart Circ Physiol. 2017; 312: H1128-H1143
- Animal models of cerebral amyloid angiopathy.Clin Sci. 2017; 131: 2469-2488
- Use of the T2*-weighted gradient recalled echo sequence for magnetic resonance imaging of the canine and feline brain.Vet Radiol Ultrasound. 2014; 55: 599-606
- Putative cerebral microbleeds in dogs undergoing magnetic resonance imaging of the head: a retrospective study of demographics, clinical associations, and relationship to case outcome.J Vet Intern Med. 2017; 31: 1140-1148
- Clinical signs and management of anxiety, sleeplessness, and cognitive dysfunction in the senior pet.Vet Clin Small Anim. 2011; 41: 565-590
- Relationships of dietary patterns, foods, and micro-and macronutrients with Alzheimer’s disease and late-life cognitive disorders: a systematic review.J Alzheimers Dis. 2017; 59: 815-849
- Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer’s disease: a focus on human studies.Pharmacol Res. 2018; 131: 32-43
- Midlife interventions are critical in prevention, delay, or improvement of Alzheimer’s disease and vascular cognitive impairment and dementia.F1000Res. 2017; https://doi.org/10.12688/f1000research.11140.1
- Neuro-nutrients as anti-Alzheimer’s disease agents: a critical review.Crit Rev Food Sci Nutr. 2018; https://doi.org/10.1080/10408398.2018.1481012
- Dietary enrichment counteracts age-associated cognitive dysfunction in canines.Neurobiol Aging. 2002; 23: 737-745
- Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy.Neurosci Biobehav Rev. 2002; 26: 679-695
- Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.Exp Gerontol. 2004; 39: 753-765
- Role of dietary pro-oxidants in the maintenance of health and resilience to oxidative stress.Mol Nutr Food Res. 2015; 59: 1229-1248
- Can a fortified food affect the behavioral manifestations of age-related cognitive decline in dogs?.Vet Med. 2003; 98: 396-408
- Pilot feasibility and safety study examining the effect of medium chain triglyceride supplementation in subjects with mild cognitive impairment: a randomized controlled trial.BBA Clin. 2015; 3: 123-125
- Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs.Br J Nutr. 2010; 103: 1746-1754
- Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerolsin healthy humans.Nutrition. 2015; 31: 1255-1259
- Metabolic perturbations associated with the consumption of a ketogenic medium chain TAG diet in dogs with idiopathic epilepsy.Br J Nutr. 2018; 120: 484-487
- Mechanism of action for medium-chain triglyceride ketogenic diets in neurological and metabolic disorders.Lancet Neurol. 2018; 17: 84-93
- Lauric acid stimulates ketone body production in the KT-5 astrocyte cell line.J Oleo Sci. 2016; 65: 693-699
- Coconut oil protects cortical neurons from amyloid beta toxicity by enhancing signaling of cell survival pathways.Neurochem Int. 2017; 105: 64-79
- Research and development of anti-Alzheimer’s disease drugs: an update from the perspective of technology flows.Expert Opin Ther Pat. 2018; 28: 341-350
- Evidence-based pharmacotherapy of Alzheimer’s disease.Int J Neuropsychopharmacol. 2004; 7: 351-369
- The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog.Neurochem Res. 1993; 18: 1211-1219
- Therapeutic efficacy of selegiline in neurodegenerative disorders and neurological diseases.Curr Drug Targets. 2006; 7: 1513-1529
- Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model.Proc Natl Acad Sci U S A. 2012; https://doi.org/10.1073/pnas.1121081109
- A mitochondrial role of SV2a protein in aging and Alzheimer’s disease: studies with levetiracetam.J Alzheimers Dis. 2016; 50: 201-215
- Levetiracetam inhibits oligomeric Aβ-induced glutamate release from human astrocytes.Neuroreport. 2016; 27: 705-709
- Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial.Vet Ther. 2008; 9: 69-82
- Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, Vitamin E, and pyridoxine.Can Vet J. 2008; 49: 379-385
- Nutritional supplementation in cases of canine cognitive dysfunction-a clinical trial.Appl Anim Behav Sci. 2007; 105: 274-283
- Neuroprotective effects of cognitive enrichment.Ageing Res Rev. 2006; 5: 354-369
- Ageing Res Rev. 2018; 47: 159-167
- Change in fitness and the relation to change in cognition and neuropsychiatric symptoms after aerobic exercise in patients with mild Alzheimer’s disease.J Alzheimers Dis. 2018; 65: 137-145
- Network pharmacology-based study on the mechanism of action for herbal medicines in Alzheimer treatment.J Ethnopharmacol. 2016; https://doi.org/10.1016/j.jep.2016.11.034
- Chinese herbal medicine for vascular dementia: a systematic review and meta-analysis of high-quality randomized controlled trials.J Alzheimers Dis. 2018; 62: 429-456
- Effect of Chinese herbal medicine on Alzheimer’s disease.Int Rev Neurobiol. 2017; 135: 29-56
- Natural products against Alzheimer’s disease: pharmaco-therapeutics and biotechnological interventions.Biotechnol Adv. 2017; 35: 178-216
- Herbal medicine for the treatment of vascular dementia: an overview of scientific evidence.Evid Based Complement Alternat Med. 2016; https://doi.org/10.1155/2016/7293626
- Pharmacological effects of active components of Chinese herbal medicine in the treatment of Alzheimer’s disease: a review.Am J Chin Med. 2016; 44: 1525-1541
- Ethnopharmacological approaches for dementia therapy and significance of natural products and herbal drugs.Front Aging Neurosci. 2018; 10: 1-24
- Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: a review.Bioorg Chem. 2017; 75: 50-61
- Vascular contributions to cognitive impairment and treatments with traditional Chinese medicine.Evid Based Complement Alternat Med. 2016; https://doi.org/10.1155/2016/9627258
- Natural phytochemicals in the treatment and prevention of dementia: an overview.Molecules. 2016; 21: 518
- Potential benefits of phytochemicals against Alzheimer’s disease.Proc Nutr Soc. 2017; 76: 106-112
- Herbal medicine for management of the behavioural and psychological symptoms of dementia (BPSD): a systematic review and meta-analysis.J Psychopharmacol. 2016; https://doi.org/10.1177/0269881116675515
- Decrease in the generation of amyloid-β due to salvianolic acid B by modulating BACE1 activity.Curr Alzheimer Res. 2017; 14: 1229-1237
- Salvia (sage): a review of its potential cognitive-enhancing and protective effects.Drugs R D. 2017; 17: 53-64
- Network pharmacology-based analysis of Chinese herbal Naodesheng formula for application to Alzheimer’s disease.Chin J Nat Med. 2018; 16: 53-62
- Adding Chinese herbal medicine to conventional therapy brings benefits to patients with Alzheimer’s disease: a retrospective analysis.BMC Complement Altern Med. 2017; 17: 1-7
- Cognitive improvement during treatment for mild Alzheimer’s disease with a Chinese herbal formula: a randomized controlled trial.PLoS One. 2015; https://doi.org/10.1371/journal.pone.0130353
- LW-AFC, a new formula derived from Liuwei Dihaung decoction, ameliorates behavioral and pathological deterioration via modulating the neuroendocrine-immune system in PrP-hAβPPswe/PS1ΔE9 transgenic mice.Alzheimers Res Ther. 2016; https://doi.org/10.1186/s13195-0226-6
- Liuwei Dihuang decoction facilitates the induction of long-term potentiation (LTP) in senescence accelerated mouse/prone 8 (SAMP8) hippocampal slices by inhibiting voltage-dependent calcium channels (VDDCs) and promoting N-methyl-D-aspartate receptor (NMDA) receptors.J Ethnopharmacol. 2012; 140: 384-390
- The effect of Sailoutong (SLT) on neurocognitive and cardiovascular function in healthy adults: a randomized, double-blind, placebo-controlled crossover pilot trial.BMC Complement Altern Med. 2016; https://doi.org/10.1186/s12906-016-0989-0
- Rationale and design of a multicenter, phase 2 clinical trial to investigate the efficacy of traditional Chinese medicine sailuotong in vascular dementia.J Stroke Cerebrovasc Dis. 2014; 23: 2626-2634
- The efficacy and safety of Fufangdanshen tablets (Radix Salviae miltiorrrhizae formula tablets) for mild to moderate vascular dementia: a study protocol for a randomized controlled trial.Trials. 2016; 17: 281
- A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine “ba wei di huang wan” in the treatment of dementia.J Am Geriatr Soc. 2004; 52: 1518-1521
- A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients.J Clin Psychiatry. 2005; 66: 248-252
- Effects of acupuncture on Alzheimer’s disease in animal-based research.Evid Based Complement Alternat Med. 2017; https://doi.org/10.1155/2017/6512520
- Acupuncture plus herbal medicine for Alzheimer’s disease: a systematic review and meta-analysis.Am J Chin Med. 2017; 45: 1327-1344
- Long-term acupuncture treatment has a multi-targeting regulation on multiple brain regions in rats with Alzheimer’s disease: a positron emission tomography study.Neural Regen Res. 2017; 12: 1159-1165
- Acupuncture for patients with mild to moderate Alzheimer’s disease: a randomized controlled trial.BMC Complement Altern Med. 2017; 17: 556
- Activation of brain glucose metabolism ameliorating cognitive impairment in APP/PS1 transgenic mice by electroacupuncture.Free Radic Biol Med. 2017; 112: 174-190
- Modulation of neurogenesis via neurotrophic factors in acupuncture treatments for neurological diseases.Biochem Pharmacol. 2017; 141: 132-142
- Acupuncture improves dendritic structure and spatial learning and memory ability of Alzheimer’s disease mice.Neural Regen Res. 2018; https://doi.org/10.4103/1673-5374.235292
- Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI.PLoS One. 2018; https://doi.org/10.1371/journal.pone.0196933
- Neuronal specificity of acupuncture in Alzheimer’s disease and mild cognitive impairment patients: a functional MRI study.Evid Based Complement Alternat Med. 2018; https://doi.org/10.1155/2018/7619197
- Mechanisms of acupuncture on vascular dementia–a review of animal studies.Neurochem Int. 2017; 107: 204-210
- Applications of acupuncture therapy in modulating plasticity of central nervous system.Neuromodulation. 2017; https://doi.org/10.1111/ner.12724
- Mechanisms underlying the effect of acupuncture on cognitive improvement: a systematic review of animal studies.J Neuroimmune Pharmacol. 2014; 9: 492-507
- Laser acupuncture improves memory impairment in an animal model of Alzheimer’s disease.J Acupunct Meridian Stud. 2013; 6: 247-251
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Published online: March 05, 2019
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