The nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of heterogeneous compounds
other than steroids that suppresses one or more substances produced during inflammatory
reactions. NSAIDs are extensively used in both human and veterinary medicine for their
antipyretic, anti-inflammation, and analgesic properties. Chemically, most NSAIDs
are substituted organic acids. Although most NSAIDs consist of a wide range of pharmacologically
active agents with diverse chemical structures and properties, they have similar therapeutic
and adverse effects associated with their use. Each year the ASPCA Animal Poison Control
Center (APCC) receives hundreds of cases involving acute accidental ingestion of human
and veterinary approved NSAIDs in dogs and cats. The purpose of this article is provide
a brief overview on the classification, mechanism of action, and pharmacologic and
toxicologic properties of most commonly encountered human and veterinary NSAIDs in
dogs and cats. For this purpose, the top 10 most frequently reported NSAIDs, as reported
to the APCC in dogs and cats from 2005 to 2010, were selected. The article discusses
general information about NSAIDs—classification, uses, pharmacokinetics, mechanisms
of actions, and treatment followed by specific toxicity information involving the
top 10 NSAIDs reported to the APCC.
Keywords
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The authors have nothing to disclose.
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© 2012 Published by Elsevier Inc.
