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Xylitol Toxicosis in Dogs

Published:January 09, 2012DOI:https://doi.org/10.1016/j.cvsm.2011.12.003
      The 5-carbon sugar alcohol xylitol is used as a sweetener in many products including gums, candies, and baked goods. In recent years the use of xylitol has increased due to the popularity of low-carbohydrate diets and low–glycemic index foods.
      • Gare F.
      The sweet miracle of xylitol.
      Xylitol also prevents oral bacteria from producing acids that damage the surfaces of teeth, leading to its inclusion in toothpaste and other oral care products.
      • Gare F.
      The sweet miracle of xylitol.
      • Cronin J.R.
      Xylitol: a sweet for healthy teeth and more.
      While xylitol is considered safe in humans, canine ingestions have resulted in severe and life-threatening signs associated with increased insulin secretion leading to hypoglycemia. Acute death due to severe hypoglycemia if untreated is possible, and liver failure may develop 1 to 3 days after xylitol ingestion.

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      References

        • Gare F.
        The sweet miracle of xylitol.
        Basic Health Publications, North Bergen (NJ)2003
        • Cronin J.R.
        Xylitol: a sweet for healthy teeth and more.
        Altern Complement Ther. 2003; 9: 139-141
        • Dunayer E.K.
        New findings on the effects of xylitol ingestion in dogs.
        Vet Med. 2006; 12: 791-796
        • Dills W.L.
        Sugar alcohols as bulk sweeteners.
        Annu Rev Nutr. 1989; 9: 161-186
        • Todd J.M.
        • Powell L.P.
        Xylitol intoxication associated with fulminant hepatic failure in a dog.
        J Vet Emerg Crit Care. 2007; 17: 286-289
        • Budavari S.
        The Merck index: an encyclopedia of chemicals, drugs, and biologicals. Merck, Rahway (NJ)1989: 9996
        • Anthony J.P.
        • Weber L.P.
        • Alkemade S.
        Blood glucose and liver function in dogs administered a xylitol drinking water additive at zero, one and five times dosage rates.
        Vet Sci Dev. 2011; 1: 7-9
        • Kuzuya T.
        • Kanazawa Y.
        • Kosaka K.
        Stimulation of insulin secretion by xylitol in dogs.
        Endocrinology. 1969; 84: 200-207
        • Froesch E.R.
        • Jakob A.
        The metabolism of xylitol.
        in: Sipple H.L. McNutt K.W. Sugars in nutrition. Academic Press, New York1974: 241-258
        • Kuzuya T.
        • Kanazawa Y.
        • Kosaka K.
        Plasma insulin response to intravenously administered xylitol in dogs.
        Metabolism. 1966; 15: 1149-1152
        • Hirata Y.
        • Fujisawa M.
        • Sato H.
        • et al.
        Blood glucose and plasma insulin responses to xylitol administered intravenously in dogs.
        Biochem Biophys Res Commun. 1966; 24: 471-475
        • Kuzuya T.
        • Kanazawa Y.
        • Hayashi M.
        • et al.
        Species difference in plasma insulin responses to intravenous xylitol in man and several mammals.
        Endocrinol Jpn. 1971; 18: 309-320
        • Xia Z.
        • He Y.
        • Yu J.
        Experimental acute toxicity of xylitol in dogs.
        J Vet Pharmacol Ther. 2009; 32: 465-469
        • Dunayer E.K.
        • Gwaltney-Brant S.M.
        Acute hepatic failure and coagulopathy associated with xylitol ingestion in eight dogs.
        J Am Vet Med Assoc. 2006; 229: 1113-1117
        • Wang Y.M.
        • King S.M.
        • Patterson J.H.
        • et al.
        Mechanism of xylitol toxicity in the rabbit.
        Metabolism. 1973; 22: 885-894
        • Brin M.
        • Miller O.N.
        The safety of oral xylitol.
        in: Sipple H.L. McNutt K.W. Sugars in nutrition. Academic Press, New York1974: 591-606
        • Kvist C.L.
        • Andersson S.B.
        • Berglund J.
        • et al.
        Equipment for drug release testing of medicated chewing gums.
        J Pharm Biomed Anal. 2000; 22: 405-411
        • Plumb D.C.
        Veterinary drug handbook.
        in: 6th ed. PharmaVet/Ames (IA): Blackwell, Stockholm (WI)2005: 14-15 (91–2, 1086–7, 1101–2)
        • Poppenga R.
        Treatment.
        in: Plumlee K.H. Clinical veterinary toxicology. Mosby, St Louis (MO)2004: 15
        • Cope R.B.
        A screening study of xylitol binding in vitro to activated charcoal.
        Vet Hum Toxicol. 2004; 46: 336-337