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- Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States.J Am Vet Med Assoc. 1999; 214: 1336-1341
- AAFP and AFM panel report of feline senior health care.Compend Contin Educ Pract Vet. 1999; 21: 531-539
- Geriatrics in canine and feline internal medicine.Eur J Med Res. 1998; 3: 31-41
- Changing perspectives on aging and energy requirements: aging and energy intakes in humans, dogs and cats.J Nutr. 1998; 128: 2623S-2626S
- Effect of age on maintenance energy requirements and apparent digestibility of canine diets [abstract].Compend Contin Educ Pract Vet. 2000; 22: 113
- Maintenance energy requirement of dogs: what is the correct value for the calculation of metabolic body weight in dogs?.J Nutr. 1991; 121: S39-S40
- Effect of age on maintenance energy requirements of adult cats.Compend Contin Edu Pract Vet. 2002; 24: 82
- Long-term food consumption and body weight changes in a controlled population of geriatric cats [abstract].Compend Contin Educ Pract Vet. 2004; 26: 60
- The inter-organ flux of substrates in fed and fasted man, an indicated by arterio-venous balance studies.Nutr Res Rev. 1991; 4: 3-31
- Factors influencing lean body mass in aging dogs.Compend Contin Educ Pract Vet. 1999; 21: 34-37
- Cat nutrition: what's new in the old?.Compend Contin Educ Pract Vet. 2004; 26: 5-10
- Changes in body composition and energy balance with aging.Vet Clin Nutr. 1996; 3: 83-87
- Influence of age on apparent digestive function and energy intake in cats [abstract].Compend Contin Educ Pract Vet. 2002; 24: 83
Finco DR. Effects of dietary protein and phosphorus on the kidney of dogs. In: Proceedings of the Waltham/OSU Symposium. Vernon, CA: Kal Kan Foods, Inc.; 1992. p. 39–41.
- Effects of aging and dietary protein intake on uninephrectomized geriatric dogs.Am J Vet Res. 1994; 55: 1282-1290
- Effects of dietary protein intake on renal functions.Vet Forum. 1999; 16: 34-44
- Mythology of protein restriction for dogs with reduced renal function.Compend Contin Educ Pract Vet. 1999; 21: 15-20
- Determination of optimal dietary protein requirements of young and old dogs.J Nutr. 1966; 88: 66-74
- Age-related changes in protein synthesis.Rev Biol Res Aging. 1983; 1: 255-273
- Effect of moderate protein deficiency on immune function.Compend Contin Educ Pract Vet. 1999; 21: 21-24
- IgE responses in mice fed moderate protein deficient and high protein diets.J Nutr Sci Vitaminol. 2003; 49: 172-178
- Effects of dietary protein on whole-body protein turnover and endocrine function in young-adult and aging dogs.J Anim Sci. 2001; 79: 3128-3136
- Effect of dietary protein on nitrogen balance and lean body mass in cats [abstract].Vet Clin Nutr. 1996; 3: 30
- Nutrient digestibility in old versus young cats.Compend Cont Educ Pract Vet. 2005; (in press)
- Older cats with gastrointestinal disease are more likely to be cobalamin deficient [abstract].Compend Contin Educ Pract Vet. 2004; 26: 62
- Vitamin E: introduction to biochemistry and health benefits.Ann NY Acad Sci. 1989; 570: 1-6
- Role of free radicals in aging and disease.Ann NY Acad Sci. 1992; 673: 126-141
- Oxidative damage and defense.Am J Clin Nutr. 1996; 63: 985S-990S
- Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation.J Biol Chem. 2000; 275: 20069-20076
- Reactive oxygen species contribute to contractile dysfunction following rapid ventricular pacing in dogs.Int J Cardiol. 2002; 83: 125-131
- The plasma superoxide scavenging activity in canine cancer and hepatic disease.J Vet Med Sci. 2003; 65: 465-469
- The role of free radicals in canine counterpart of senile dementia of the Alzheimer type.Exp Gerontol. 2003; 38: 711-719
- Glutathione metabolism and its implications for health.J Nutr. 2004; 134: 489-492
- Effect of vitamin E deficiency on the proliferative response of canine lymphocytes.Am J Vet Res. 1981; 42: 1681-1685
- Vitamin E, immune response, and disease resistance.Ann NY Acad Sci. 1989; 570: 335-344
- Effects of antioxidants on immune system aging.Eur J Clin Nutr. 2002; 56: S5-S8
- Effects of dietary cysteine on blood sulfur amino acid, glutathione, and malondialdehyde concentrations in cats.Am J Vet Res. 1999; 60: 328-333
- Antioxidant prevention and treatment of Heinz body formation and oxidative injury in cats [abstract].Compend Contin Educ Pract Vet. 2000; 22: 90
- Role of dietary antioxidants to protect against DNA damage in adult dogs.J Nutr. 2002; 132: 1720S-1724S
- Antioxidant status of adult beagles is affected by dietary antioxidant intake.J Nutr. 2002; 132: 1658S-1660S
- Effects of age and dietary beta-carotene on immunological variables in dogs.J Vet Intern Med. 2003; 17: 835-842
- Cause and control of decreased appetite.in: Kirk R.W. Current veterinary therapy X. WB Saunders, Philadelphia1989: 18-24
- Immediate appetite stimulation of anorexic cats with midazolam [abstract].Compend Contin Educ Pract Vet. 2004; 26: 61
- Immediate appetite stimulation of anorexic dogs with propofol [abstract].Compend Contin Educ Pract Vet. 2004; 26: 64
- Effects of diet restriction on life span and age-related changes in dogs.J Am Vet Med Assoc. 2002; 220: 1315-1320
- Associations between body condition and disease in cats.J Am Vet Med Assoc. 1998; 212: 1725-1731
- Tumor necrosis factor-α levels in adipose tissue of lean and obese cats.J Nutr. 1998; 128: 2751S-2752S
- Pro-inflammatory cytokines and adipose tissue.Proc Nutr Soc. 2001; 60: 349-356
- Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial.Am J Clin Nutr. 2004; 79: 544-551
- Insulin resistance and changes in plasma concentration of TNFα, IGF1, and NEFA in dogs during weight gain and obesity.J Anim Physiol Anim Nutr. 2004; 88: 157-165
- C-reactive protein as a biomarker of emergent osteoarthritis.Osteoarthritis Cartilage. 2002; 10: 595-601
- Oxidative stress is associated with adiposity and insulin resistance in men.J Clin Endocrinol Metab. 2003; 88: 4673-4676
- Evidence for contribution of vascular NAD(P)H oxidase to increased oxidative stress in animal models of diabetes and obesity.Free Radic Biol Med. 2004; 37: 115-123
- Early spay-neuter in the cat: effect on development of obesity and metabolic rate.Vet Clin Nutr. 1995; 2: 132-134
- Effects of neutering on bodyweight, metabolic rate and glucose tolerance of domestic cats.Res Vet Sci. 1997; 62: 131-136
- Ad libitum feeding following ovariectomy in female Beagle dogs: effect on maintenance energy requirement and on blood metabolites.J Anim Physiol Anim Nutr. 2004; 88: 117-121
- Effects of feeding regimens on bodyweight, composition and condition score in cats following ovariohysterectomy.J Small Anim Pract. 2001; 42: 433-438
- Development and validation of a body condition score system for cats: a clinical tool.Feline Pract. 1997; 25: 13-18
- Development and validation of a body condition score system for dogs: a clinical tool.Canine Pract. 1997; 22: 10-15
- Comparison of various methods for estimating body fat in dogs.J Am Anim Hosp Assoc. 2004; 40: 109-114
- Effects of an ad libitum low-fat, high-carbohydrate diet on body weight, body composition and fat distribution in older men and women: a randomized, controlled trial.Arch Intern Med. 2004; 164: 210-217
- Differential metabolic effects of energy restriction in dogs using diets varying in fat and fiber content.Obes Res. 1996; 4: 337-345
- Very-low-carbohydrate weight-loss diets revisited.Cleveland Clin J Med. 2002; 69: 849-862
- A randomized trial of a low-carbohydrate diet for obesity.N Engl J Med. 2003; 348: 2082-2090
- A low-carbohydrate as compared with a low-fat diet in severe obesity.N Engl J Med. 2003; 348: 2074-2081
- Increased dietary protein spares lean body mass during weight loss in dogs [abstract].J Vet Intern Med. 1998; 12: 224
Laflamme DP, Hannah SS. Effect of dietary protein on composition of weight loss in cats [abstract]. In: Proceedings of the British Small Animal Veterinary Association. Birmingham, England; 1998. p. 277.
- Randomized trial on protein vs carbohydrate in ad libitum fat reduced diet for the treatment of obesity.Int J Obes. 1999; 23: 528-536
- Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women.Am J Clin Nutr. 2003; 78: 31-39
- A reduced ratio of dietary carbohydrate to protein improves body composition and blood lipid profiles during weight loss in adult women.J Nutr. 2003; 133: 411-417
- High-protein, low-fat diets are effective for weight loss and favorably alter biomarkers in healthy adults.J Nutr. 2004; 134: 586-591
- Diet-induced thermogenesis in man: thermic effects of single proteins, carbohydrates and fats depending on their energy amount.Ann Nutr Metab. 1984; 28: 245-252
- The influence of thermic effect of food on satiety.Eur J Clin Nutr. 1997; 52: 482-488
- The significance of protein in food intake and body weight.Curr Opin Clin Nutr Metab Care. 2003; 6: 635-638
- High protein intake sustains weight maintenance after body weight loss in humans.Int J Obes. 2004; 28: 57-64
Armstrong PJ, Hardie EM, Cullen JM, et al. l-carnitine reduced hepatic fat accumulation during rapid weight loss in cats. J Vet Int Med 1992;6:127.
- Necessity of carnitine supplementation in semistarved rats fed a high-fat diet.Nutrition. 2001; 17: 628-631
- Plasma and urinary carnitine of obese subjects on very-low-calorie diets.J Am Coll Nutr. 1990; 9: 261-264
- Dietary fat intake, supplements and weight loss.Can J Appl Physiol. 2000; 25: 495-523
- l-carnitine supplementation combined with aerobic training does not promote weight loss in moderately obese women.Int J Sport Nutr Exerc Metab. 2000; 10: 199-207
- Effect of l-carnitine on weight loss and body composition of rats fed a hypocaloric diet.Ann Nutr Metab. 2002; 46: 205-210
- Carnitine supplementation fails to maximize fat mass loss induced by endurance training in rats.Ann Nutr Metab. 2004; 48: 90-94
- Effect of dietary carnitine or chromium on weight loss and body composition of obese dogs [abstract].J Anim Sci. 1998; 76: 175
- Effect of dietary carnitine during energy restriction in the canine.FASEB J. 1999; 13 ([abstract 226.2]): A268
- The clinical and metabolic effects of rapid weight loss in obese pet cats and the influence of supplemental oral l-carnitine.J Vet Intern Med. 2000; 14: 598-608
- The effect of weight loss regimen on subsequent weight maintenance in dogs.Nutr Res. 1995; 15: 1019-1028
- Epizootiologic patterns of diabetes mellitus in cats: 333 cases (1980 – 1986).J Am Vet Med Assoc. 1990; 197: 1504-1508
- Time trends and risk factors for diabetes mellitus in cats [abstract].J Vet Intern Med. 2003; 17: 434
- Glucose tolerance and insulin response in normal-weight and obese cats.Am J Vet Res. 1990; 51: 1357-1362
- Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain.J Feline Med Surg. 2001; 3: 211-228
- Skeletal muscle triglycerides lowering is associated with net improvement of insulin sensitivity, TNF-α reduction and GLUT4 expression enhancement.Int J Obes. 2002; 26: 1165-1172
- GLUT4 but not GLUT1 expression decreases early in the development of feline obesity.Domest Anim Endocrinol. 2004; 26: 291-301
- Diet in the prevention of diabetes and obesity in companion animals [abstract].Asia Pac J Clin Nutr. 2004; 12: S6
- Comparative aspects of diabetes mellitus in dogs and cats.Mol Cell Endocrinol. 2002; 197: 221-229
- The link between obesity and diabetes in cats and dogs. In: Proceedings of the North American Veterinary Conference, Orlando, FL. 2003; : 292-293
- Dietary management of diabetes mellitus.J Small Anim Pract. 1992; 33: 213-217
- Dietary fiber and postprandial hyperglycemia in normal and diabetic dogs.J Small Anim Pract. 1990; 31: 229-233
- Effects of dietary fiber supplementation on glycemic control in dogs with alloxan-induced diabetes mellitus.Am J Vet Res. 1991; 52: 2060-2066
- Influence of a high fiber diet on glycemic control and quality of life in dogs with diabetes mellitus.J Small Anim Nutr. 2002; 43: 67-73
- Dietary fiber decreases fasting blood glucose levels and plasma LDL concentration in noninsulin-dependent diabetes mellitus patients.Am J Clin Nutr. 1988; 47: 852-858
- The role of fiber in managing diabetes mellitus.Vet Med. 1989; 84: 1156-1160
- Effects of insoluble and soluble dietary fiber on glycemic control in dogs with naturally occurring insulin-dependent diabetes mellitus.J Am Vet Med Assoc. 2000; 216: 1076-1081
Fleeman LM, Rand JS, Markwell PJ. Diets with high fiber and moderate starch are not advantageous for dogs with stabilized diabetes compared to a commercial diet with moderate fiber and low starch. J Vet Intern Med 2003;17:433.
- Effect of dietary insoluble fiber on control of glycemia in cats with naturally acquired diabetes mellitus.J Am Vet Med Assoc. 2000; 216: 1082-1088
- Use of a high protein diet in the management of feline diabetes mellitus.Vet Ther. 2001; 2: 238-246
- Comparison of a low carbohydrate diet versus high fiber diet in cats with diabetes mellitus [abstract].J Vet Intern Med. 2001; 15: 297
- The glycemic response to isoglucogenic quantities of protein and carbohydrate.J Clin Invest. 1936; 15: 665-671
- Utility of a short-term 25% carbohydrate diet on improving glycemic control in type 2 diabetes mellitus.J Am Coll Nutr. 1998; 17: 595-600
- An increase in dietary protein improves the blood glucose response in persons with Type 2 diabetes.Am J Clin Nutr. 2003; 78: 734-741
- Treatment of feline diabetes mellitus using an alpha-glucosidase inhibitor and a low-carbohydrate diet.J Feline Med Surg. 2003; 5: 183-189
- The effects of subject-selected high carbohydrate, low fat diets on glycemic control in insulin dependent diabetes mellitus.Am J Clin Nutr. 1985; 41: 293-298
- The impact of dietary protein restriction on insulin secretion and action.Proc Nutr Soc. 1999; 58: 647-653
- Effect of dietary protein intake on insulin secretion and glucose metabolism in insulin-dependent diabetes mellitus.J Clin Endrocrinol Metab. 1996; 81: 3938-3943
- Protein and fat effects on glucose responses and insulin requirements in subjects with insulin-dependent diabetes mellitus.Am J Clin Nutr. 1993; 58: 555-560
- Increased urea synthesis in insulin-dependent diabetic dogs maintained normoglycemic: effect of portal insulin administration and food protein content.Diabetes. 1996; 45: 667-674
- Understanding the pathophysiology of osteoarthritis.Vet Med. 2002; 97: 108-112
- Osteoarthritis. Joint anatomy, physiology and pathobiology.Vet Clin N Am Small Anim Pract. 1997; 27: 699-723
- Osteoarthritis and body weight.Nutr Res. 2000; 20: 899-903
- Relationship between body weight gain and significant knee, hip and back pain in older Americans.Obes Res. 2003; 11: 1159-1162
- C-reactive protein as a biomarker of emergent osteoarthritis.Osteoarthritis Cartilage. 2002; 10: 595-601
- Weight loss to optimal body condition increases ground reactive force in dogs with osteoarthritis.Compend Contin Educ Pract Vet. 2001; 23 ([abstract]): 74
- Effect of weight reduction on clinical signs of lameness in dogs with hip osteoarthritis.J Am Vet Med Assoc. 2000; 216: 1089-1091
- Effects of carprofen and dexamethasone on canine chondrocytes in a three-dimensional culture model of osteoarthritis.Am J Vet Res. 2002; 63: 1363-1369
- The effect of deracoxib, a new COX-2 inhibitor, on the prevention of lameness induced by chemical synovitis in dogs.Vet Ther. 2002; 3: 7-18
- Analgesia and COX-2 inhibition.Clin Exp Rheumatol. 2001; 19: S63-S70
- The therapeutic effect of carprofen (Rimadyl) in 209 clinical cases of canine degenerative joint disease.Vet Comp Orthop Traumatol. 1992; 5: 140-144
- Role of eicosanoids in structural degradation in osteoarthritis.Curr Opin Rheumatol. 2003; 15: 623-627
- Marine oils and their effects.Nutr Rev. 1992; 50: 38-45
- Nutritional modulation of inflammatory diseases.Semin Vet Med Surg. 1997; 12: 212-222
- Plasma and neutrophil phospholipid n-3 fatty acid composition is independent of the n-6/n-3 fatty acid ratio [abstract].Compend Contin Educ Pract Vet. 2000; 22: 99
- Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.Arthritis Rheum. 2002; 46: 1544-1553
- Omega-3 polyunsaturated fatty acids and skeletal health.Exp Biol Med. 2001; 226: 485-497
- Nutritional management of osteoarthritis.Vet Clin N Am Small Anim Pract. 1997; 27: 883-911
- Treatment of dogs with hip arthritis with a fatty acid supplement.Canine Pract. 1992; 17: 6-8
Hansen RA, Waldron MK, Allen KGD, et al. Long chain n-3 PUFA improve biochemical parameters associated with canine osteoarthritis. In: Proceedings of the American Oil Chemists Society Meeting, Cincinnati, OH, May 9–12, 2004. Champagne (IL): American Oil Chemists Society.
- Oral chondroprotective agents. Part I Common compounds.Compend Contin Educ Pract Vet. 1999; 21: 601-609
- Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis.Arch Intern Med. 2003; 163: 1514-1522
- Comparison of the anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis.J Rheumatology. 1996; 23: 1385-1391
- Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis.Osteoarthritis and Cartilage. 1998; 6: 31-36
- Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study.Osteoarthritis and Cartilage. 1998; 6: 39-46
- Condroitins 4 and 6 sulphate in osteoarthritis of the knee: a randomized, controlled trial.Arthritis Rheum. 2005; 52: 779-786
- Systems to assess the progression of finger joint osteoarthritis and the effects of disease modifying osteoarthritic drugs.Clin Rheumatol. 2002; 21: 231-243
- In vivo chondroprotection and metabolic synergy of glucosamine and chondroitin sulfate.Clin Orth Rel Res. 2000; 381: 229-240
- Scintigraphic evaluation of dogs with acute synovitis after treatment with glucosamine hydrochloride and chondroitin sulfate.Am J Vet Res. 1999; 60: 1552-1557
- Comparison of the concentrations of pentosidine in the synovial fluid, serum and urine of patients with rheumatoid arthritis and osteoarthritis.Rheumatology. 1999; 38: 1275-1278
- Synovial fluid interleukin 6, tumor necrosis factor, and nitric oxide values in dogs with osteoarthritis secondary to cranial cruciate ligament rupture.Am J Vet Res. 1997; 58: 1027-1032
- Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis.J Rheumatol. 1981; 8: 233-245
- Oxidative stress induces chondrocyte telomere instability and chondrocyte dysfunctions in osteoarthritis [abstract].Arthritis Res Ther. 2003; 5: 164
- The role of reactive oxygen species in homeostasis and degradation of cartilage.Osteoarthritis Cartilage. 2003; 11: 747-755
- Mediation of spontaneous knee osteoarthritis by progressive chondrocyte ATP depletion in Hartley guinea pigs.Arthritis Rheum. 2004; 50: 1216-1225
- Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis.J Biol Chem. 2000; 275: 20069-20076
- Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence.J Gerontol. 2004; 59: 324-336
- Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women.Am J Epidemiol. 2003; 157: 345-354
- Supplementary vitamin E does not affect the loss of cartilage volume in knee osteoarthritis: a 2 year double blind randomized placebo controlled study.J Rheumatol. 2002; 29: 2585-2591
- Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice.Osteoarthritis Cartilage. 2002; 10: 119-126
- Nutrient intake of patients with rheumatoid arthritis is deficient in pyridoxine, zinc, copper, and magnesium.J Rheumatol. 1996; 23: 990-994
- Inadequate calcium, folic acid, vitamin E, zinc, and selenium intake in rheumatoid arthritis patients: results of a dietary survey.Semin Arthritis Rheum. 1998; 27: 180-185