As veterinarians, we find ourselves in a rather awkward position regarding our knowledge
about the most common feline heart disease, hypertrophic cardiomyopathy (HCM) [
1
,
2
]. In the last decade, we have made great progress in our understanding of the disease;
yet, we now find ourselves armed with reasonable evidence that there is a great deal
we still do not know. We have established that HCM is a heterogeneous disease [
3
,
4
,
5
,
6
,
7
,
8
,
9
] and have increasing evidence of a potentially large pool of asymptomatic cats with
HCM that are not routinely identified [
3
,
4
,
8
,
9
]. Although families of cats with HCM seem to be more similar with regard to clinical
manifestations and disease progression, the disparities among unrelated cats with
HCM are dramatic. Important questions regarding the genetics of the disease persist
despite great efforts to collect, characterize, and even breed families of cats found
to be affected by the disease. More importantly, we have not convincingly established
many useful risk factors that should help us to guide owners with regard to their
pet's prognosis. An important step toward selecting appropriate therapy for cats with
HCM that have been presented with diastolic heart failure (HF) has been made with
a blind, multicenter, placebo-controlled, prospective clinical trial [
[10]
].Fox PR, for the Multicenter Feline Chronic Heart Failure Study Group Prospective. Double-blinded, multicenter evaluation of chronic therapies for feline diastolic heart failure: interim analysis [abstract]. In: Proceedings of the 21st Forum of the American College of Veterinary Internal Medicine. Charlotte, NC, 2003.
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References
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Article info
Footnotes
☆Catherine J Baty, DVM, PhD, is a recipient of a Burroughs Wellcome Fund Hitchings-Elion Fellowship.
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© 2004 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
