Current research in canine and feline pheromones

      Everyone who has observed dogs or cats, if only once, has been impressed by how important olfactory communication is in these species. Carnivora are known as the order that has developed the greatest variety of glands secreting chemical signals. Among all the molecules secreted by these glands, some seem to transmit highly specific information between animals of the same species—the pheromones. In 1959, Karlson, Luscher, and Butenand created this word by combining the Greek verbs pherein (to carry) and horman (to stimulate). Initially, this kind of chemical communication was supposed to exist only in invertebrates. At that time, more attention was paid to the pheromones of insects, and a few products to fight against some pests have been developed. Many ethologists thought that this really strict and biologic way to communicate should not be considered in mammals because of the complexity and plasticity of their social behaviors [
      • Bossert W.H.
      • Wilson E.O.
      The analysis of olfactory communication among animals.
      ].
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      References

        • Bossert W.H.
        • Wilson E.O.
        The analysis of olfactory communication among animals.
        J Theor Biol. 1963; 5: 443-469
        • Alberts A.C.
        Constraints on the design of chemical communication systems in terrestrial vertebrates.
        Am Nat. 1992; 139: S62-S89
        • MacDonald D.W.
        The carnivores: order Carnivora.
        in: Brown R.E. MacDonald D.W. Social odours in mammals. Clarendon Press, Oxford1985: 619-722
      1. Pageat P. Properties of cat's facial pheromones. European Patent EP 0 724 832 B1. February 3, 1995.

        • Pageat P.
        Functions and uses of the facial pheromones in the treatment of urine marking in the cat.
        in: Johnston D. Waner T. Proceedings of the XX1st Congress of the World Small Animal Veterinary Association, Jerusalem, 1996. WSAVA, 1996
        • Stoddart D.M.
        The ecology of vertebrate olfaction.
        Chapman and Hall, London1980
        • Adams D.R.
        • Wiekamp M.D.
        The canine vomeronasal organ.
        J Anat. 1984; 38: 771-787
        • Wada A.
        • Kogure N.
        • Mizoguchi S.
        • et al.
        Topographic anatomical study of the feline vomeronasal organ.
        Bull Coll Agr Vet Med. 1991; 48: 89-97
        • Meredith M.
        Sensory processing in the main and accessory olfactory systems: comparisons and contrasts.
        J Steroid Biochem Mol Biol. 1991; 39: 601-614
        • Halpern M.
        The organisation and function of the vomeronasal system.
        Annu Rev Neurosci. 1987; 10: 325-362
        • Keverne E.B.
        The vomeronasal organ.
        Science. 1999; 286: 716-720
        • Salazar I.
        • Sanchez Quinteiro P.
        • Cifuentes J.M.
        Comparative anatomy of the vomeronasal cartilage in mammals: mink, cat, dog, cow and horse.
        Ann Anat. 1995; 177: 475-481
        • Salazar I.
        • Sanchez Quinteiro P.
        • Cifuentes J.M.
        • Garcia Caballero T.
        The vomeronasal organ of the cat.
        J Anat. 1996; 188: 445-454
        • Eccles R.
        Autonomic innervation of the vomeronasal organ of the cat.
        Physiol Behav. 1982; 28: 1011-1015
      2. Guiraudie G, Pageat P, Nagnan-Le Meillour P. Sus scrofa odorant protein m-RNA. GeneBank NCBI April 17, 2002.

        • Karn R.C.
        The mouse salivary androgen binding protein (ABP) alpha subunit closely resembles chain 1 of the allergen Fel d 1.
        Biochem Genet. 1996; 32: 271-277
      3. Tessier Y. Dosage de l'allergène majeur Fel d 1 produit par le chat (Felis silvestris catus L.) en fonction de son état émotionnel. Mémoire pour le D.E.A. de Biosciences de l'environnement et santé. Marseille; 1999

        • Pageat P.
        La communication dans l'univers des carnivores domestiques.
        Point Vét. 1997; 28: 1055-1063
        • Dicke M.
        • Sabelis M.W.
        Infochemical terminology: based on cost-benefit analysis rather than origin of compounds?.
        Funct Ecol. 1988; 2: 131-139
        • Bekoff M.
        Scent marking by free ranging domestic dogs: olfactory and visual components.
        Biol Behav. 1979; 4: 123-139
        • de Boer J.N.
        The age of olfactory cues functioning in chemocommunication among male domestic cats.
        Behav Processes. 1977; 2: 209-225
        • Doty R.L.
        Odor-guided behavior in mammals.
        Experiencia. 1986; 42: 257-271
        • Zielonka T.M.
        • Charpin D.
        • Berbis P.
        • et al.
        Effects of castration and testosterone on Fel d 1 production by sebaceous glands of male cats: I—immunological assessment.
        Clin Exp Allergy. 1994; 24: 1169-1173
        • Pageat P.
        • Tessier Y.
        Usefulness of the F4 synthetic pheromone for preventing intraspecific aggression in poorly socialized cats.
        in: Mills D.S. Heath S.E. Harrington L.J. Proceedings of the First International Conference on Veterinary Behavioural Medicine, Birmingham, 1997. UFAW, Herts, UK1997: 64
        • Pageat P.
        • Tessier Y.
        F4 synthetic pheromone: a means to enable handling of cats with a phobia of veterinarian, during consultation.
        in: Mills D.S. Heath S.E. Harrington L.J. Proceedings of the First International Conference on Veterinary Behavioural Medicine, Birmingham, 1997. UFAW, Herts, UK1997: 108
        • Pageat P.
        Pathologie du comportement du chien. 2nd edition. Ed. Le Point Vétérinaire, Paris1998 (p. 28–32)
        • Carayol N.
        • Birnbaum J.
        • Magnan A.
        • et al.
        Fel d 1 production in the cat skin varies according to anatomical sites.
        Allergy. 2000; 55: 570-573
        • Bekoff M.
        Ground scratching by male domestic dogs: a composite signal.
        J Mammal. 1979; 60: 847-848
        • Albone E.S.
        • Gosden P.E.
        • Ware G.C.
        • et al.
        Bacterial action and chemical signalling in the red fox, Vulpes vulpes, and other mammals.
        Proc Am Chem Soc. 1978; 67: 78-91
        • Donovan C.A.
        Canine anal glands and chemical signals (pheromones).
        JAVMA. 1969; 155: 1995-1996
        • Ashdown R.R.
        Symposium on canine recto-anal disorders.
        J Small Anim Pract. 1968; 9: 315-322
        • Preti G.
        • Meutterties E.L.
        • Furman J.
        • et al.
        Volatile constituents of dog (Canis familiaris) and coyote (Canis latrans) anal sacs.
        J Chem Ecol. 1976; 2: 177-187
        • Dornelas de Andrade A.
        • Birnbaum J.
        • Magalon C.
        • et al.
        Fel d 1 levels in cat anal glands.
        Clin Exp Allergy. 1996; 26: 178-180
        • Gorman L.
        • Trownbridge B.
        The role of odor in the social lives of carnivores.
        in: Gittleman J.L. Carnivore behavior, ecology and evolution. Cornell University Press, Ithaca1989: 57-88
        • Goodwin M.
        • Gooding K.M.
        • Reginer F.
        Sex pheromone in the dog.
        Science. 1979; 203: 559-561
      4. Pageat P. Pig appeasing pheromone to decrease stress, anxiety and aggressiveness. United States Patent 6,077,867. June 20, 2000.

        • Johnson R.P.
        Scent marking in mammals.
        Anim Behav. 1973; 21: 521-535
        • Doty R.L.
        • Dunbar I.
        Attraction of beagles to conspecific urine, vaginal and anal sac secretion odours.
        Physiol Behav. 1974; 12: 825-833
        • Pageat P.
        • Tessier Y.
        Usefulness of the F3 synthetic pheromone Feliway in preventing behaviour problems in cats during holidays.
        in: Mills D.S. Heath S.E. Harrington L.J. Proceedings of the First International Conference on Veterinary Behavioural Medicine, Birmingham, 1997. UFAW, Herts, UK1997: 231
        • Gaultier E.
        • Pageat P.
        • Tessier Y.
        Effect of a feline appeasing pheromone analogue on manifestations of stress in cats during transport.
        in: Veissier I. Boissey A. Proceedings of the 32nd Congress of the International Society for Applied Ethology, Clermont-Ferrand, 1998. INRA, 1998: 198
      5. Frank D. Treatments of spraying cats. In: Proceedings of the Annual Convention of the American Veterinary Medical Association, Baltimore, 1998. p. 225–6.

        • Frank D.
        • Erb H.N.
        • Houpt K.A.
        Urine spraying in cats: presence of concurrent disease and effects of pheromone treatment.
        Anim Behav Sci. 1999; 61: 263-272
      6. Hunthausen W. Evaluation of the use of pheromone analogue (Feliway) to control urine marking in cats. In: Proceedings of the American Veterinary Society of Animal Behavior, Baltimore, 1998. p. 6–7.

        • Hunthausen W.
        Evaluating a feline facial pheromone analogue to control urine spraying.
        Vet Med. 2000; 143: 151-156
      7. Landsberg G. Case challenge series—feline housesoiling. In: Proceedings of the North American Veterinary Clinics, Orlando, 2001. p. 47–9.

        • Mills D.S.
        • White J.C.
        Long-term follow up of the effect of a pheromone therapy on feline spraying behaviour.
        Vet Rec. 2000; 147: 746-747
        • Mills D.S.
        • Mills C.B.
        Evaluation of a novel method for delivering a synthetic analogue of feline facial pheromone to control urine spraying by cats.
        Vet Rec. 2001; 149: 197-199
        • Mills D.S.
        Pheromonotherapy—an integral part of modern companion animal practice.
        UK Vet. 2002; 7: 1-3
        • Ogata N.
        • Takeuchi Y.
        Clinical trial with a feline pheromone analogue for feline urine marking.
        J Vet Med Sci. 2001; 63: 157-161
        • White J.C.
        • Mills D.
        Efficacy of synthetic feline facial pheromone (F3) analogue (Feliway) for the treatment of chronic non-sexual urine spraying by the domestic cat.
        in: Mills D.S. Heath S.E. Harrington L.J. Proceedings of the First International Conference on Veterinary Behavioural Medicine, Birmingham, 1997. UFAW, Herts, UK1997
        • Pageat P.
        Experimental evaluation of the efficacy of a synthetic analogue of cat's facial pheromones (Feliway) in inhibiting urine marking of sexual origin in adult tom-cats.
        J Vet Pharmacol Ther. 1997; 20: 169
      8. Mertens PA. Sniffing around for information on feline olfaction. In: Proceedings of the North American Veterinary Conference, Orlando, 2001. p. 52.

      9. Kronen PW, Ludders JW, Erb HN, et al. The F3-fraction of feline facial pheromones calms cats prior to intravenous catheterization. In: Proceedings of the 7th World Congress of Veterinary Anaesthesia, Berne, 2000. p. 71.

      10. Griffith C, Steigerwals E, Buffington CAT. Effects of a synthetic facial pheromone on behavior and food intake of caged cats. In: Proceedings of the 3rd ESVCN Congress, Lyon, 1999.

        • Kakuma Y.
        • Bradshaw J.W.S.
        Effects of feline facial pheromone analogue on stress in shelter cats.
        in: Overall K.L. Mills D.S. Heath S.E. Horwitz D. Proceedings of the 3rd International Congress on Veterinary Behavioural Medicine, Vancouver, 2001. UFAW, Herts, UK2001
        • Pageat P.
        • Gaultier E.
        Treatment of separation anxiety in dogs with a synthetic dog appeasing pheromone-preliminary results.
        in: Dehasse J. Biosca Marce E. Proceedings of the 8th ESVCE Meeting on Veterinary Behavioural Medicine. Publibook, Paris2002: 49-54

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